Orexin A (Hypocretin-1)

Orexin A, also known as Hypocretin-1, is an important component of the orexin/hypocretin neuropeptide system. Mature human Orexin A is a 33-amino-acid neuropeptide characterized by its disulfide-bonded structure.

Orexin A interacts with both OX1R (Orexin Receptor 1) and OX2R (Orexin Receptor 2), making it an important research peptide for investigating orexin receptor biology and downstream cellular signaling.

In neuroscience research, Orexin A is investigated in connection with sleep-wake regulation, neuronal excitability, feeding behavior, energy homeostasis, autonomic function, and neuroendocrine signaling. Research also examines its interactions with multiple neurotransmitter networks and their roles in arousal and metabolic regulation.

Orexin A is intended as a neuropeptide research material, and experimental findings should not be interpreted as established therapeutic or health benefits in humans.

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